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Table 2 Methodological quality of observation studies with EBRO assessment tool of cohort studies [38]

From: The Contribution of Advanced Glycation End product (AGE) accumulation to the decline in motor function

Item

Semba et al. 2010 [45]

Sun et al. 2012 [46]

Whitson et al. 2014 [47]

Shah et al. 2015 [50]

Dalal et al. 2009 [43]

De La Maza et al. 2008 [49]

Momma et al. 2011 [44]

Tanaka et al. 2015 [48]

1. Are the comparing groups clearly described?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

2. Can risk of bias sufficiently be excluded?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

3. Is the exposure clearly described and is the method for assessing the exposure adequate?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

4. Is outcome clearly described and is the method for assessing the outcome adequate?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

5. Has exposure outcome been blinded?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

6. Is there sufficient long follow-up?

Not Applicable

Yes

Yes

Not Applicable

Not Applicable

Not Applicable

Not Applicable

Not Applicable

7. Can selective loss-to-follow-up sufficiently be excluded?

Not Applicable

Yes

Yes

Not Applicable

Not Applicable

Not Applicable

Not Applicable

Not Applicable

8. Have important confounders or prognostic factors been identified and are they taken into account in the design or analysis?

Yes

Yes

Yes

No

Yes

No

Yes

Yes

9. Are the study results valid and applicable?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

10. Correction for potential confounders: Odds ratio (OR), Relative Risk (RR), Absolute Risk Reduction (ARR), Mean Difference (MD), Hazard Ratio (HR)

Yes

Yes

Yes

No

Yes

No

Yes

Yes

Overall quality score

Good

Good

Good

Moderate

Good

Moderate

Good

Good

  1. To be eligible for further statistical analysis, the study results should rate “valid and applicable” or “doubtful” on question 9. To qualify “valid and applicable” a longitudinal study had to score “Yes” on the 2 follow up questions (6 and 7) and more than 4 times a “yes” on the remaining validity items (1 t/m5 and 8). A “doubtful” qualification was given when 4 times a “yes” was scored on the remaining validity items (1 t/m5 and 8). When a study scored “yes” less than 4 times on the remaining items, further analysis with the checklist was cancelled. When the study had a cross-sectional design the two questions regarding follow up (6 and 7) were disregarded