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Table 2 Grades of recommendation (reproduced with the permission of the SIGN group)

From: Effects of Tai Chi exercises on self-efficacy and psychological health

Grades of recommendation
1++ High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias
1+ Well conducted meta-analyses, systematic reviews of RCTs, or RCTs with a low risk of bias
1 Meta-analyses, systematic reviews of RCTs, or RCTs with a high risk of bias
2++ High quality systematic reviews of case control or cohort or studies
High quality case-control or cohort studies with a very low risk of confounding, bias, or chance and a high probability that the relationship is causal
2+ Well conducted case-control or cohort studies with a low risk of confounding, bias, or chance and a moderate probability that the relationship is causal
2 Case control or cohort studies with a high risk of confounding , bias, or chance and a significant risk that the relationship is not causal
3 Nonanalytic studies, e.g., case reports, case series
  1. RCT Randomized controlled trial