Fig. 1

Sequence of events responsible for the formation of advanced glycation end products (AGEs). The reaction between glucose molecules and protein amino groups forms the reversible Schiff base that suffers an intramolecular rearrangement, leading to a less reversible Amadori product. In some conditions, these Amadori products form AGEs through a dicarbonyl intermediate such as 3-deoxyglucosone. According to Ahmed [2]