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Table 1 Intention-to-treat and per-protocol analyses of prolactin concentrations between high and moderate volume exercise groups in BETA, (n = 386)

From: Physical activity does not alter prolactin levels in post-menopausal women: results from a dose-response randomized controlled trial

Group

n

Baseline

6 Months

12 Months

Treatment effect

Between-group Pc

Geometric Meana

95% CI

Geometric Mean

95% CI

Geometric Mean

95% CI

Ratio of High/Moderateb

95% CI

Intention-to-treat

0.90

 High

195

9368

8720 – 10064

9353

8741–10008

9035

8467 – 9641

1.00

0.95 – 1.06

 Moderate

191

9331

8713 – 9992

9230

8644–9855

9017

8457 – 9613

  

Per-protocold

0.62

 High

80

8761

8002 – 9591

9158

8225–10198

8700

7904 – 9576

1.02

0.93 – 1.13

 Moderate

58

9653

8284 – 11248

9251

8110–10551

9366

8275 – 10600

  
  1. aGeometric mean of prolactin was in the unit of pg/mL
  2. bThe geometric mean ratios were estimated from least square means for the difference in treatment effect between high and moderate volume exercisers averaged across the entire study period adjusted for the baseline values and then back log-transformed
  3. c P value corresponds to the null hypothesis that the ratio of treatment effect between high- and moderate-volume groups equals 1 against the 2-sided alternative hypothesis
  4. dWomen assigned to the moderate-volume group were adherent if they completed 90% to 100% of the exercise prescription (mean, 135–150 min/week), weeks 13 to 52 at full prescription; women assigned to the high-volume group were adherent if they completed at least 90% of the exercise prescription (mean, ≥270 min/week), weeks 13 to 52 at full prescription