Table 5 Ongoing RCTs from clinicaltrials.gov investigating the effects of exercise-based interventions exclusively in older patients (≥ 65 years) with cancer undergoing medical antineoplastic treatment
Trial identifier | Title | Investigator, country | Cancer diagnoses | Treatment setting | No. | Age | Exercise type and duration | Duration | Delivery of intervention | Primary outcome | Study status |
|---|---|---|---|---|---|---|---|---|---|---|---|
NCT03656731 | Exercise in older women with breast cancer during systemic therapy – BREACE | Lund, Denmark | Breast cancer | (Neo)adjuvant or first or second-line palliative systemic treatment | 100 | ≥ 65 years | Team-based progressive resistance training + homed-based walking | 12 weeks | Supervised and unsupervised | Lower body extremity strength | Recruiting Study completion: December 2021 |
NCT03411200 | Patient activation through counseling, exercise and mobilization (PACE-Mobil) | Mikkelsen, Denmark | Pancreatic, biliary tract, and lung cancer | Palliative treatment with CT, IT or TT. ≤ 3 months of diagnosis | 100 | ≥ 65 years | Team-based progressive resistance training + homed-based walking | 12 weeks | Supervised and unsupervised | Lower body extremity strength | Recruiting Study completion: January 2021 |
NCT03955627 | REJOIN trial for older breast cancer survivors | Bluethmann, USA | Stage I, II or III breast cancer | Completed surgery, radiation and/or CT. Planning to initiate treatment with aromatase inhibitors | 76 | ≥ 65 years | Exercise consultation and the Fit & Strong exercise program; low-impact aerobic exercise and resistance training. Bi-weekly exercise (60 min.) and educational sessions (30 min.) | 16 weeks | Supervised (8 weeks) and unsupervised (8 weeks) | Change in pain (joint pain) | Not yet recruiting Study completion: January 2022 |
NCT04057443 | Nutritional and physical exercise intervention in older patients with malignant hemopathies (ICOSENIORHEM) | Antonio, Spain | Myelodysplastic syndromes, lymphoproliferative syndromes, and multiple myeloma | Recently diagnosed | 80 | ≥ 70 years | Group-based program of “mixed structure”. + nutritional support | During treatment or max. 6 months. | Supervised | Adherence to oncological treatment | Recruiting Study completion: June 2021 |
NCT03100175 | Strength and aerobic training in elderly lymphoma patients during chemotherapy and its impact on treatment outcomes, patients functioning and biological markers of aging | Vaxman, Israel | Large B cell lymphoma, Hodgkin lymphoma, or follicular lymphoma | Newly diagnosed. Planned for at least 75% of full dose CT | 100 | ≥ 70 years | Homed-based resistance training, brisk walking, and balance exercises + telephone call 2 x weekly | NR | Unsupervised | Treatment tolerance | Unknown status Last registered study completion date: March 2019 |
Study protocol published in BMC cancer [31] PMID: 31151425 | A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study | Miura, Japan | Advanced non-small cell lung cancer or inoperable pancreatic cancer | Scheduled for systemic cancer therapy (i.e. CT, and/or TT and/or IT | 130 | ≥ 70 years | Muscle training (3–5 exercises, daily training), physical activity advice, and nutritional counseling and supplements, which are all individualized. | 12 weeks + follow-up (including advice) until death or disability | Unsupervised | Disability-free survival | Recruitment ongoing at February 26, 2019 |