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Table 3 SNPs in skeletal muscle eQTLs associated with training-responsive genes and handgrip strength

From: Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Training-associated gene

 

SNP

Variant ID

eQTL p-values for skeletal muscle expression

eQTL p-values for handgrip strength

HSPG2

Heparan Sulfate Proteoglycan 2

rs71636995

chr1_21877520_C_T_b38

1.40E-05

3.87E-03

CYP4B1

Cytochrome P450 Family 4 Subfamily B Member 1

rs11211375

chr1_46836964_A_G_b38

9.20E-20

3.50E-03

HIBCH

3-Hydroxyisobutyryl-CoA Hydrolase

rs201160834

chr2_190304632_A_AT_b38

3.40E-08

2.04E-03

RFTN2

Raftlin Family Member 2

rs68022726

chr2_197566490_A_G_b38

5.60E-05

6.69E-03

DGKD

Diacylglycerol Kinase Delta

rs76145205

chr2_233584763_G_T_b38

4.40E-06

1.99E-03

SCAP

SREBF Chaperone

rs62260743

chr3_47541718_C_T_b38

7.00E-05

7.18E-03

NOA1

Nitric Oxide Associated 1

rs1277271

chr4_56971181_T_C_b38

1.30E-08

2.12E-03

DHFR

Dihydrofolate Reductase

rs26266

chr5_80744875_T_C_b38

3.70E-41

6.05E-03

NQO2

N-Ribosyldihydronicotinamide: Quinone Reductase 2

rs28383595

chr6_3001234_T_C_b38

2.50E-08

5.97E-03

NOTCH4

Notch Receptor 4

rs1281934

chr6_32616605_A_G_b38

9.70E-08

3.78E-08

CSGALNACT1

Chondroitin Sulfate

N-Acetylgalactosaminyltransferase 1

rs11204056

chr8_19596883_C_T_b38

4.70E-11

9.93E-03

ANK1

Ankyrin 1

rs62508166

chr8_41679800_G_A_b38

4.20E-09

8.91E-03

COL15A1

Collagen Type XV Alpha 1 Chain

rs7026938

chr9_98875916_C_T_b38

2.80E-05

9.15E-03

TRPT1

TRNA Phosphotransferase 1

rs72924202

chr11_64365756_C_T_b38

1.30E-18

1.31E-03

FZD4

Frizzled Class Receptor 4

rs611538

chr11_87125491_T_G_b38

5.30E-07

7.85E-03

CEP57

Centrosomal Protein 57

rs571413

chr11_95793424_C_T_b38

1.30E-14

2.03E-03

STX2

Syntaxin 2

rs7137314

chr12_130756804_C_T_b38

3.80E-12

7.86E-03

TMTC1

Transmembrane O-Mannosyltransferase Targeting Cadherins 1

rs11050591

chr12_29971149_C_A_b38

1.50E-06

8.41E-03

RCBTB2

RCC1 And BTB Domain Containing Protein 2

rs7991892

chr13_47942622_C_T_b38

6.80E-05

1.60E-03

PPP1R15A

Protein Phosphatase 1 Regulatory Subunit 15A

rs4802517

chr19_48878914_T_C_b38

3.50E-05

7.90E-03

ACSS1

Acyl-CoA Synthetase Short Chain Family Member 1

rs6049932

chr20_24738298_C_G_b38

3.90E-06

6.57E-03

GSS

Glutathione Synthetase

rs3891369

chr20_34573323_C_T_b38

7.70E-07

6.66E-06

ACSS2

Acyl-CoA Synthetase Short Chain Family Member 2

rs6058105

chr20_34683915_C_T_b38

3.60E-08

1.63E-06

JPH2

Junctophilin 2

rs77792994

chr20_44130642_G_A_b38

9.40E-05

9.23E-03

MICAL3

Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 3

rs56076143

chr22_17898151_C_T_b38

5.70E-05

2.18E-03

MAPK12

Mitogen-Activated Protein Kinase 12

rs2294394

chr22_50071829_T_C_b38

1.10E-05

6.61E-04

  1. Variant ID refers to chromosome_position_ref_alt_build (ref reference nucleotide, alt alternative nucleotide, build genome build version)