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Table 3 HRs and 95% CIs for the association between physical activity trajectory and cancer risk in both sexes

From: Trajectory of physical activity frequency and cancer risk: Findings from a population-based cohort study

 

Men

Women

Cases*

Model 1α

Model 2β

Cases*

Model 1α

Model 2β

 

HR (95%CI)

HR (95%CI)

 

HR (95%CI)

HR (95%CI)

All cancers

 Low

59,000

1.00

1.00

25,388

1.00

1.00

 Moderate

12,676

0.97 (0.95–0.98)

0.99 (0.97–1.01)

4972

1.01 (0.98–1.04)

1.00 (0.97–1.03)

 High-to-low

3659

0.98 (0.94–1.01)

0.99 (0.96–1.02)

1316

0.98 (0.93–1.04)

0.98 (0.93–1.04)

 Low-to-high

3626

0.98 (0.95–1.02)

0.99 (0.96–1.03)

1342

0.98 (0.93–1.04)

0.97 (0.92–1.03)

 High

3007

0.98 (0.95–1.02)

1.01 (0.98–1.05)

1093

0.94 (0.89–1.00)

0.92 (0.87–0.98)

Colorectum

 Low

8739

1.00

1.00

2669

1.00

1.00

 Moderate

1799

0.92 (0.88–0.97)

0.95 (0.90–1.00)

479

0.97 (0.88–1.07)

0.96 (0.87–1.06)

 High-to-low

524

0.95 (0.87–1.03)

0.97 (0.88–1.06)

149

0.94 (0.80–1.10)

0.93 (0.79–1.09)

 Low-to-high

525

0.97 (0.89–1.06)

0.99 (0.91–1.09)

152

0.96 (0.82–1.13)

0.96 (0.82–1.13)

 High

437

0.98 (0.89–1.08)

1.02 (0.93–1.13)

122

0.92 (0.77–1.10)

0.91 (0.76–1.10)

Liver

 Low

5512

1.00

1.00

837

1.00

1.00

 Moderate

1173

0.96 (0.90–1.02)

1.00 (0.94–1.07)

158

1.03 (0.87–1.22)

1.05 (0.88–1.24)

 High-to-low

321

0.97 (0.87–1.09)

1.00 (0.89–1.12)

67

1.25 (0.97–1.60)

1.24 (0.97–1.59)

 Low-to-high

320

1.00 (0.89–1.12)

1.01 (0.90–1.13)

43

0.88 (0.66–1.19)

0.82 (0.60–1.11)

 High

241

0.92 (0.81–1.05)

1.00 (0.88–1.14)

43

1.00 (0.74–1.35)

0.99 (0.73–1.35)

Lung

 Low

7069

1.00

1.00

1639

1.00

1.00

 Moderate

1196

0.76 (0.72–0.81)

0.88 (0.82–0.93)

338

1.09 (0.97–1.22)

1.10 (0.97–1.23)

 High-to-low

444

0.89 (0.81–0.98)

1.01 (0.91–1.11)

101

1.05 (0.86–1.28)

1.03 (0.84–1.26)

 Low-to-high

474

0.93 (0.85–1.02)

1.01 (0.92–1.11)

99

1.02 (0.84–1.25)

1.03 (0.84–1.26)

 High

309

0.73 (0.65–0.82)

0.90 (0.81–1.01)

89

1.07 (0.86–1.32)

1.08 (0.88–1.34)

Thyroid gland

 Low

3511

1.00

1.00

6461

1.00

1.00

 Moderate

834

1.10 (1.02–1.18)

0.99 (0.92–1.07)

1339

1.05 (0.99–1.12)

1.03 (0.97–1.10)

 High-to-low

152

0.89 (0.76–1.04)

0.83 (0.71–0.98)

277

0.99 (0.88–1.12)

0.99 (0.88–1.12)

 Low-to-high

120

0.86 (0.72–1.03)

0.80 (0.67–0.96)

303

1.02 (0.91–1.14)

1.01 (0.90–1.13)

 High

114

0.94 (0.78–1.13)

0.82 (0.68–0.99)

261

1.03 (0.91–1.16)

1.01 (0.89–1.14)

Breast

 Low

   

4444

1.00

1.00

 Moderate

   

964

1.11 (1.03–1.19)

1.06 (0.99–1.14)

 High-to-low

   

170

0.88 (0.76–1.02)

0.88 (0.75–1.02)

 Low-to-high

   

182

0.87 (0.75–1.01)

0.88 (0.76–1.02)

 High

   

150

0.86 (0.73–1.01)

0.82 (0.70–0.96)

Corpus uteri

 Low

   

573

1.00

1.00

 Moderate

   

131

1.16 (0.96–1.40)

1.11 (0.92–1.35)

 High-to-low

   

26

1.11 (0.76–1.62)

1.03 (0.70–1.53)

 Low-to-high

   

21

0.81 (0.53–1.24)

0.78 (0.50–1.20)

 High

   

28

1.21 (0.82–1.76)

1.18 (0.81–1.73)

  1. * The number of observations was different between Model 1 and Model 2 due to the missing value of covariates. The number of cases was calculated for model 2
  2. α adjusted for age
  3. β adjusted for age, income, frequency of alcohol drinking, smoking status, BMI group, and Charlson Comorbidity Index