The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB)

Bautmans, Ivan; Knoop, Veerle; Beyer, Ingo; Bruunsgaard, Helle; Molbo, Drude; Mortensen, Erik Lykke; Lund, Rikke

doi:10.1186/s11556-024-00336-9

European Review of Aging and Physical Activity

Table 4 Circulating levels of inflammatory mediators according to self-perceived fatigue and muscle endurance

From: The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB)

Parameter	HIGH Fatigue LOW Muscle Endurance	NORMAL Fatigue NORMAL Muscle Endurance	HIGH Fatigue NORMAL Muscle Endurance	NORMAL Fatigue LOW Muscle Endurance	p-value*
General Fatigue	n = 119	n = 431	n = 225	n = 154
Log hsCRP (pg/mL)	0.213 ± 0.42^a	0.015 ± 0.022^b	0.040 ± 0.030^b	0.008 ± 0.036^b	< 0.001
Log IL-6 (pg/mL)	0.348 ± 0.032^a	0.193 ± 0.017^b	0.280 ± 0.023^a	0.260 ± 0.032	< 0.001
Log TNF-α (pg/mL)	0.695 ± 0.018	0.654 ± 0.009	0.667 ± 0.013	0.685 ± 0.016	0.137
Log IL-10 (pg/mL)	0.156 ± 0.057	0.064 ± 0.030	0.068 ± 0.042	0.214 ± 0.05	0.043
Log IFN-γ (pg/mL)	-0.346 ± 0.036	-0.389 ± 0.019	-0.320 ± 0.026	-0.396 ± 0.036	0.130
Physical Fatigue	n = 102	n = 454	n = 202	n = 171
Log hsCRP (pg/mL)	0.184 ± 0.046^a	-0.016 ± 0.021^b	0.109 ± 0.032^a	0.049 ± 0.034	< 0.001
Log IL-6 (pg/mL)	0.353 ± 0.035^a	0.191 ± 0.016^b	0.293 ± 0.025^a	0.268 ± 0.026	< 0.001
Log TNF-α (pg/mL)	0.688 ± 0.020	0.649 ± 0.009	0.679 ± 0.014	0.690 ± 0.020	0.046
Log IL-10 (pg/mL)	0.160 ± 0.063	0.091 ± 0.030	0.009 ± 0.044	0.204 ± 0.047^c	0.018
Log IFN-γ (pg/mL)	-0.364 ± 0.040	-0.387 ± 0.019	-0.317 ± 0.028	-0.379 ± 0.030	0.220
Reduced Activity	n = 113	n = 438	n = 218	n = 160
Log hsCRP (pg/mL)	0.182 ± 0.043^a	-0.015 ± 0.021^b	0.100 ± 0.031^a	0.039 ± 0.035	< 0.001
Log IL-6 (pg/mL)	0.363 ± 0.033^a	0.184 ± 0.016^b	0.300 ± 0.024^a	0.254 ± 0.027	< 0.001
Log TNF-α (pg/mL)	0.709 ± 0.018^a	0.641 ± 0.009^b	0.694 ± 0.013^a	0.677 ± 0.015	0.001
Log IL-10 (pg/mL)	0.207 ± 0.059	0.050 ± 0.030	0.097 ± 0.043	0.178 ± 0.049	0.037
Log IFN-γ (pg/mL)	-0.347 ± 0.037	-0.381 ± 0.019	-0.334 ± 0.027	-0.393 ± 0.031	0.388
Reduced Motivation	n = 121	n = 436	n = 220	n = 152
Log hsCRP (pg/mL)	0.159 ± 0.041^a	-0.008 ± 0.022^b	0.085 ± 0.031	0.047 ± 0.037	0.002
Log IL-6 (pg/mL)	0.316 ± 0.031^a	0.186 ± 0.017^b	0.296 ± 0.023^a	0.284 ± 0.028^a	< 0.001
Log TNF-α (pg/mL)	0.696 ± 0.018	0.650 ± 0.009	0.677 ± 0.013	0.684 ± 0.016	0.052
Log IL-10 (pg/mL)	0.194 ± 0.057	0.038 ± 0.030	0.119 ± 0.042	0.187 ± 0.051	0.019
Log IFN-γ (pg/mL)	-0.341 ± 0.036	-0.384 ± 0.019	-0.329 ± 0.027	-0.401 ± 0.032	0.228
Mental Fatigue	n = 104	n = 467	n = 189	n = 168
Log hsCRP (pg/mL)	0.190 ± 0.044^a	-0.001 ± 0.021^b	0.083 ± 0.033	0.038 ± 0.035^b	0.001
Log IL-6 (pg/mL)	0.263 ± 0.034	0.189 ± 0.016	0.307 ± 0.025^a	0.318 ± 0.027^a	< 0.001
Log TNF-α (pg/mL)	0.685 ± 0.019	0.649 ± 0.009	0.684 ± 0.014	0.691 ± 0.015	0.031
Log IL-10 (pg/mL)	0.141 ± 0.061	0.032 ± 0.029	0.150 ± 0.046	0.216 ± 0.048^a	0.005
Log IFN-γ (pg/mL)	-0.383 ± 0.039	-0.382 ± 0.018	-0.324 ± 0.029	-0.369 ± 0.030	0.373

ANCOVA analysis (with weekly physical activity, percentage body fat and presence of inflammatory conditions as covariates); values are expressed as adjusted mean ± SE; ^asignificantly different from participants with NORMAL Fatigue & NORMAL Muscle Endurance (Bonferroni post hoc test p < 0.05); ^bsignificantly different from participants with HIGH Fatigue & LOW Muscle Endurance. (Bonferroni post hoc test p < 0.05); ^csignificantly different from participants with HIGH Fatigue & NORMAL Muscle Endurance (Bonferroni post hoc test p < 0.05)

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