The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review

Older patients with cancer are underrepresented in trials investigating the effect of exercise therapy. The aim of this systematic review was to investigate the effect of exercise therapy during medical antineoplastic treatment in older patients (≥ 65 years) with cancer. A systematic review following the Cochrane guidelines was performed. Randomized controlled trials were identified through a systematic literature search in MEDLINE, EMBASE, CENTRAL, and CINAHL up to December 2019. Study selection was performed independently by two reviewers. Four randomized controlled trials published between 2014 and 2019 were included comprising a total of 412 participants. Most participants were diagnosed with breast, prostate or colorectal cancer. The studies were characterized by large differences in design, interventions and outcomes, which prevented meta-analyses. The interventions ranged from 4 weeks to 12 months and involved both supervised and unsupervised exercise programs. Some evidence of beneficial effects from the interventions were documented on physical function, muscle strength, physical activity and cognitive function. No evidence of effects was found for health-related quality of life, aerobic capacity, body composition, cancer-related symptoms and side effects, or for any clinical outcomes. No adverse events were reported. Exercise therapy seems to be safe and feasible in older patients with cancer. However, due to a limited number of studies, small sample sizes and heterogeneity across study design, the effects of exercise in older patients with cancer receiving medical antineoplastic treatment are inconclusive.


Introduction
The role of physical activity (PA) and exercise in cancer prevention, treatment and rehabilitation has been widely investigated and discussed in the last decades. There is increasing evidence that a physically active lifestyle lowers the risk of some cancers [1]. The strongest evidence for a risk reduction has been demonstrated in breast, endometrial, colon, gastric, kidney, bladder and esophageal cancer [1][2][3][4][5][6][7][8]. In a recently published systematic review, the relative risk reductions ranged from approximately 10 to 20% [1]. In addition to PA playing a preventive role, studies have shown that patients with higher PA levels had lower risk of breast and colon cancer-specific mortality [9][10][11]. After a cancer diagnosis, several studies have demonstrated that exercise can maintain or increase muscle mass and strength, aerobic capacity, functional mobility and health-related quality of life (HRQoL) in patients with cancer and cancer survivors [12,13]. However, most of the conducted studies have been performed among younger patients with cancer [14][15][16]. In 2016, the Cancer and Aging Research Group provided a review focusing on exercise-based trials among older adults with cancer [16]. Only seven studies were identified in which the mean age of the study populations reached 60 years or more. Furthermore, most studies included cancer survivors in the posttreatment period [16]. Similarly, in a recently published systematic review focusing on effects of nutrition and physical activity interventions among older patients with cancer, the researchers had to lower their initial age cut-off criterion from ≥70 to ≥60 years of age, as they did not find any studies in the initial search. Even with a cut-off of ≥60 years and with inclusion of all treatments (and non-treatment) only a small number of studies were identified [17].
The risk of cancer increases with aging [18]. In 2012, 47.5% of all cancers worldwide were diagnosed among older adults (≥ 65 years), while only 8% of the world population is in this age group [18]. Natural aging causes physiological changes, including decreased organ function [19][20][21], loss of muscle mass [22] and reduced bone mineral density [23]. In addition, comorbidity increases with age and heightens the risk of disability and mortality [24]. Agerelated changes in health place older adults in additional risk of short and long-term disability when diagnosed with cancer [25]. Due to recruitment challenges and exclusion criteria, older patients with cancer have been underrepresented in exercise-based intervention studies [16]. Therefore, it is unlikely that these trial results can be generalized to the older cancer population. The primary aim of this systematic review was to investigate the effect of exercisebased interventions on HRQoL and physical function. Secondarily, we looked at the effects of exercise interventions on aerobic capacity, muscle strength, body composition, cancer and treatment-related side effects, feasibility of the interventions, and survival/mortality in older patients (≥ 65 years) with cancer during medical antineoplastic treatment.

Registrations
The study protocol was registered at the international prospective register of systematic reviews PROSPERO on April 11, 2019 (Reg. ID: CRD42019128349).

Data sources and searches
A comprehensive search was conducted in four databases: MEDLINE, EMBASE, CENTRAL and CINAHL. A matrix that consisted of the following search focus was conducted and used in all the databases: a) exercise, b) cancer, c) older adults, and d) randomized controlled trials (RCTs). Applied search words according to the search focus are shown in Additional file 1: Appendix A. A broad search strategy was chosen to capture all relevant exercise-based studies, as we expected only few eligible studies in this research field based on the findings from Kilari et al. [16] The search was conducted using free text words and indexed terms for search focus a-c. RCTs were identified using the Cochrane Collaboration highly sensitive search strategy. In addition, a manual search of references in the included studies was conducted. No restrictions were used for either language or time of publication. The search was updated on December 9, 2019.

Study selection criteria
Studies were included if they fulfilled the following criteria: 1) Investigated the effect of an exercise-based intervention defined as resistance training, aerobic, balance or flexibility exercises. Programs including active stretching exercises were accepted (e.g. focusing on specific cancer-related joint problems/decreased range of motion), whereas programs solely including passive stretching exercises were excluded. Mixed exercise interventions consisting of a specific exercise program such as pilates or yoga were accepted. Multimodal programs were accepted if at least 50% of the intervention time included exercise; 2) Included patients with cancer in medical antineoplastic treatment. All types of solid cancers and hematologic malignancies were included. Medical antineoplastic treatment was defined as chemotherapy, endocrine therapy, targeted therapy, immunotherapy or combinations of these. Studies that included different treatment regimens were accepted if at least 50% of the participants received medical antineoplastic treatments; 3) Exclusively included older adults (≥ 65 years); 4) Were RCTs, including randomized cross-over and feasibility trials; 5) Reported on at least one of the following outcomes; HRQoL, physical function, aerobic capacity, muscle strength, body composition, cancer and treatment-related symptoms and side effects, or survival/mortality.

Outcomes
The primary outcomes of interest were changes in HRQoL and in physical function. Measures of HRQoL included both generic and cancer specific patient-reported outcome measures (PROMs). Physical function is closely related to activities of daily living, and all measures of physical functioning (including PROMs) were included. Secondary outcomes included changes in aerobic capacity (maximal oxygen uptake (VO2max) or substitute measures), muscle strength, body composition, cancer and treatment-related symptoms and side effects, feasibility (recruitment rate, retention, drop-outs and adherence), safety, and survival/ mortality. Additional outcomes that were investigated in the included studies will also be reported.

Risk of bias
Risk of bias in the included studies was assessed using the Cochrane Risk of Bias Tool (RoB2) [26]. RoB2 is the latest updated version of the Cochrane risk-of-bias tool for randomized trials. It is used to assess the risk of bias due to the randomization process, deviations from the intended interventions, missing outcome data, measurement of the outcome, and selection of reported results. The assessment is conducted using a series of signaling questions and results in judgements of "low", "some concerns" or "high" risk of bias [26]. The overall risk of bias was judged as "high risk" if one or more domains were judged "high risk" of bias, or if three or more domains were judged as "some concerns". Low risk of bias was only judged in studies that were judged "low risk" of bias in all five domains. Risk of bias assessment for each study was performed independently by two authors [MKM and DLN]. Any disagreements were resolved by discussion, or if necessary, by consulting a third author [CBJ].

GRADE assessment
We intended to perform meta-analyses and to assess the overall quality of evidence using the Grading of Recommendation, Assessment, Development and Evaluation tool (GRADE) [27], as described in the preregistration of the protocol. However, due to the substantial differences between included studies regarding participants, interventions and outcomes, an overall evaluation of the effect of exercise interventions was not performed.

Statistics
As the included studies were characterized by large differences in study design, interventions and outcomes, meta-analysis was not performed and instead a narrative synthesis approach was used. The results are presented as means with standard error (SE) or medians with interquartile range (IQR).

Results
The initial search in MEDLINE, EMBASE, CENTRAL and CINAHL identified 11,074 studies. After removing duplicates, 9249 studies remained. Titles and abstracts were screened in the first review phase, leaving 38 studies for further reviewing. In full text review, a total of 34 studies were excluded, including two otherwise eligible studies in which no information on current treatment was provided [28,29]. Finally, only four studies were deemed eligible for inclusion. A 'Preferred Reporting Items for Systematic Reviews and Meta-Analysis' (PRISMA) flowchart of the identification process is shown in Fig. 1.

Study characteristics
The design and setup of the included studies are summarized in Table 1. The studies were conducted in France [30], Canada [31], USA [32], and Japan [33], and published from 2014 to 2019. The studies were all RCTs, however, one study was a pilot RCT [32]. One study [31] recruited patients who were a part of a single blinded pilot study called CANcer EXercise (CANEX) that investigated the impact of a mixed exercise program (unpublished study), with no further explanation provided. Two studies included patients with various cancers [30,31], one study included patients with breast or prostate cancer [33], and one study solely included patients with prostate cancer [32]. In three studies the inclusion criterion was age of ≥65 years [31][32][33], while one included individuals ≥70 years [30]. Two studies excluded patients who were already physically active [31,32], and two excluded patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) > 1 [33] and > 2 [30], respectively. Table 2 details the baseline characteristics of the included studies. The studies involved a total of 412 participants with a mean age ranging from 68 to 77 years. Across all studies, breast (N = 159), prostate (N = 72) and colorectal cancer (N = 66) were the most frequent diagnoses. Sample sizes in the included studies ranged from 14 to 301 participants. The primary outcome was physical function in two studies [30,32], and cognitive functioning in one study [33]. In these three studies, power calculations were presented [30,32,33]. Meanwhile, only one study achieved the desired power [33], while two did not due to higher number of drop-outs [30], standard deviations and baseline differences [32] than expected. In one study, neither the primary outcome of interest nor a power calculation were described [31].

Baseline characteristics
In the study by Arrieta et al [30], all participants were curatively treated. Miki et al [33] included patients receiving both curative and palliative treatments. In both studies > 50% of the participants received systemic oncological treatments [30,33]. Maréchal et al [31] included patients who received systemic oncological treatment that was started ≤12 weeks, with no further details provided regarding treatment setting. Finally, Sajid et al [32] included patients with prostate cancer who were treated with androgen deprivation therapy for ≥ 3 months and with stable disease.

Exercise interventions
Interventions in the included studies were characterized by large differences. Two studies involved home-based and unsupervised interventions [30,32], one was fully supervised with a personal instructor [33], and one was both supervised and unsupervised [31]. The intervention in the study by Arrieta et al [30] contained individualized phone advice on both resistance and aerobic exercises with the aim to maintain fitness. Advice on exercise frequency was given twice weekly, but hereafter all advice regarding exercise frequency, duration and intensity was individualized and not further described [30]. The study by Sajid et al [32] contained two intervention arms; the first arm, referred to as 'EXCAP', included a walking program and progressive resistance training with elastic bands. The walking program was of moderate intensity meeting 60-70% of heart rate reserve (HRR). All participants were instructed to increase their daily steps by 5-20% and to reach 10,000 steps per day. Pedometers and activity diaries were used for selfmonitoring. The resistance training program was of low to moderate intensity. The starting point was tailored to each of the participants, but all participants were encouraged to progressively increase to a maximum of 4 sets of 15 repetitions. The second intervention arm, referred to as 'Wii', was designed to deliver a similar mode, intensity and duration as EXCAP, but was delivered with Wii-fit technology and also included balance exercises [32]. The supervised  Self-reported c Participants were instructed to pedal a bicycle ergometer to match the target speed arbitrarily displayed on a computer screen. A standard path corresponding to the target number of revolutions was displayed on the computer screen (standard number of revolutions), and the participants pedaled the bicycle ergometer while visually tracking and paying attention to following the path intervention from Miki et al [33] involved speed-feedback therapy where participants pedaled a bicycle ergometer and followed the speed and path that was visually shown on a display. The exercise load was set at 20 watts with a maximum of 80 rpm [33]. In the study conducted by Maréchal et al [31], the intervention consisted of both aerobic and resistance training [31]. A progression period of 4 weeks was given to attain 40 min of aerobic workout at 70-75% of HRR and was then maintained. The resistance training comprised five exercises targeting the major muscle groups. Two to three sets with 10-15 repetitions were performed at 50-65% of participant perceived maximum [31]. Duration of the interventions in the included studies varied from four weeks to twelve months with exercise frequencies ranging between once weekly to at least five times a week. Details about the interventions are summarized in Table 1.
Three studies compared the interventions with a control group (CG) receiving usual care [30,32,33], while Maréchal et al [31] used an active stretching group as control.

Risk of bias
Overall, the studies applied proper randomization procedures. However, in the study by Maréchal et al [31] the randomization procedure was unclear, as participants were recruited from another trial. Blinding of participants were not applied in any of the studies [30][31][32][33] due to the natural difficulties of blinding participants in exercise-based trials. Blinding of outcome assessors was clearly documented in two studies [30,33]. The trial context generates a risk of participants in the control groups performing exercises on their own, which could blur results of the interventions. Sajid et al [32] used diaries and pedometer assessments for all participants, which partly provided an overview of PA performed by all participants. Overall, the risk of bias was assessed as being "high" in one study (as four out of five domains were assessed as being of "some concerns") [31], while the overall risk of bias assessment of three studies were "some concerns" [30,32,33]. The full risk of bias assessment is shown in Additional file 2: Appendix B.

Effects
The study results on physical and cognitive outcomes are shown in Table 3.

Health-related quality of life
Miki et al [33] measured the effect on HRQoL using the Functional Assessment of Cancer Therapy -General (FACT-G) and found no statistically significant differences between the groups.

Physical function
All studies reported results on physical functioning. Two studies used the Short Physical Performance Battery (SPPB) which is a group of measures combining results from gait speed, balance, and the chair stand test [30,32]. In the study by Sajid et al [32], there were no statistically significant differences in SPPB between groups from baseline to post-intervention (6 weeks). However, a mixed effects linear regression model found a mean increase over time of 1.2 points in EXCAP, compared to a nearly constant score (exact numbers not reported) in the CG (p = 0.038), while there was no statistically significant difference in the change of scores between Wii and the CG. Arrieta et al [30] found no statistically significant differences in SPPB between groups after the 12-months intervention. However, after 24 months 40.3% of participants in the CG and 24.1% in the intervention group (IG) had declined ≥1 point in SPPB score, p = 0.057. In addition, in subgroup analysis they found a statistically significant difference in SPPB in favor of the IG in women with breast cancer (decline in SPPB; CG: 45.2% vs IG: 10.7%, p = 0.006) and in participants with a normal nutritional status according to the Mini Nutritional Assessment (decline in SPPB; CG: 50.0% vs IG: 19.4%, p = 0.009) [30].
Maréchal et al [31] used the Global Physical Capacity Score (GPCS) combining six tests for function, strength and aerobic capacity and comparing score sums with a reference population and found a statistically significant difference between groups; IG: 4.0 (SE 0.2) vs CG: 1.5 (SE 0.8), p = 0.047. Furthermore, they investigated effects on physical function using the six-minute walk test. While test results were improved in both the CG (mean increase: 63.8 m (m), SE 15.8) and in the IG (mean increase: 74.8 m, SE 19.5), there was no statistically significant difference between the groups [31]. On the remaining tests regarding physical function, no statistically significant differences between groups were found for Activities of Daily Living (ADL) [33], Instrumental Activities of Daily Living (IADL) [33], Sit & Reach test [31], or 8-ft up and go test [31].

Aerobic capacity
None of the included studies reported on aerobic capacity.

Muscle strength
Muscle strength was measured in two studies. Maréchal et al [31] demonstrated an improvement in the chair stand test of 4.3 repetitions (rep.) (SE 0.9) in the IG, compared to an improvement in the CG of 1.0 rep. (SE 0.5), p = 0.01. No statistically significant differences were found between groups in the arm curl test or for one repetition maximum (1RM) leg press [31]. Sajid et al [32] found no statistically significant differences between groups in grip strength or in chest press.

Body composition
One study [32] included body composition using dual energy x-ray absorptiometry (DEXA) scans and found no differences between groups in lean body mass.

Cancer and treatment-related symptoms and side effects
None of the included studies measured potential effects on symptoms and side effects.

Feasibility
Results regarding feasibility are shown in Table 4. The mean recruitment rate, as reported by two of the included trials [30,33], was 74%. Patients were recruited through outpatient clinics at the hospitals [30,32,33], and from another exercise-based trial [31]. Barriers concerning recruitment were documented in one study; Miki et al [33] reported the following barriers: distance to hospital (31%), too busy (29%), poor physical condition (22%), not interested (10%) and other reasons (7%). Exercise adherence was reported by two studies; in the study by Arietta et al [30], the percentage of completed phone consultations was 81%, while the percentage of performed exercises was 70%. In the study by Miki et al [33], all participants completed all speed-feedback bicycle sessions. Three studies reported on adverse events [31][32][33]; all with no incidents of any events. The average attrition rate at the end of the intervention period, as reported by three studies [30,32,33], was 7%, while it on average was 35% in the full study period including follow-up [30,32].

Physical activity
Three studies investigated the effects on physical activity (PA). Sajid et al [32] found an increase of daily steps in EXCAP of 1950 steps, compared to a decrease of daily steps in the CG of 383 steps (p = 0.019), while there was no statistically significant difference between Wii (+ 1224 steps) and the CG (− 383 steps), p = 0.051. In the remaining two studies using self-reported PA, no statistically significant differences between groups were found [30,31].

Cognition
Two studies measured effects on cognition. Miki et al [33] assessed cognitive function using the Frontal Assessment Battery. Participants in the IG had a mean change from 15 [30] no differences between groups were found for cognition measured by verbal fluency.

Ongoing trials
The search on clinicaltrials.gov identified five studies, while an additional study was included as a published protocol article [34]. The inclusion age in three studies was ≥65 years, whereas three studies included patients ≥70 years. Two studies focused on patients with breast cancer, two studies included patients with hematologic malignancies, one study included patients with advanced pancreatic, biliary tract and lung cancer, and finally one study focused on patients with advanced lung and pancreatic cancer. All studies investigated the effect of a multimodal exercise program including aerobic and resistance training. The primary outcomes are lower body extremity strength (two studies), treatment tolerance/adherence (two studies), joint pain (one study) and disability-free survival (one study). Sample sizes ranged from 76 to 130 participants. The search was last updated on December 9, 2019. An overview of the studies registered at clinicaltrials.gov is shown in Table 5.

Discussion
In this systematic review, we found some evidence for beneficial effects from exercise interventions on physical function, muscle strength, physical activity and cognitive function among older patients with cancer during antineoplastic treatment. We found no evidence for any effects of exercise on HRQoL, aerobic capacity, body composition, cancer-related symptoms and side effects, or for any clinical outcomes. Overall, the results were inconclusive due to lack of sufficiently powered studies. Patients with cancer are recommended to avoid inactivity and to return to normal activities as soon as possible following diagnosis [35]. Though it is often stated that patients with cancer can perform exercise according to general recommendations for healthy people, published guidelines also emphasize the current knowledge gaps, here among lack of evidence regarding safety and effects of exercise for older patients with cancer [16,35]. Despite recommendations of staying physically active after a cancer diagnosis, most patients with cancer and cancer survivors decrease PA level and struggle to meet PA recommendations [36,37]. In a longitudinal study conducted by De Groef et al [38], self-reported levels of activity were investigated among 267 patients with breast cancer before surgery and at several following time points. After 2 years, all activity levels (total, sports, occupational and household) were statistically significantly lower compared to preoperative levels [38].
In a qualitative study focusing on exploring attitudes towards PA among older patients (≥ 65 years) with cancer during systemic oncological treatments, several barriers towards PA and exercise were identified, including physical limitations due to age-related declines in health, fatigue, and comorbidities [39]. Thus, recruitment to and adherence in exercise-based studies focusing on older patients with cancer may be challenging.
In the current review, rates of recruitment were only reported by two studies and ranging from 53% [33] to 82% [30]. Description of reasons for excluding patients in the screening process and reasons why patients declined, was not described in three studies. Knowledge about these factors are important and could guide future trials. Only two studies reported on adherence to exercise sessions, with Miki et al [33] reporting 100% adherence, and Arrieta et al [30] reported 70% adherence by self-report. Estimates of PA based on self-report are generally higher than estimates derived from objective measures [40,41]. Therefore, self-reported adherence must be interpreted with caution.
Even though some statistically significant effects were found in individual studies regarding functional capacity and lower extremity muscle strength [31,32], increased activity level [32], and cognitive improvement [33], no evidence for an effect was seen for most outcomes, and therefore the overall evidence of positive effects were sparse. There could be several explanations for this. First, due to the small sample sizes in some of the studies, there could be a risk of type II error due to lack of statistical power. Second, non-adherence to the intervention or contamination by increased activity among participants in the control groups could have negated differences between groups. Exercise-based trials may be particularly susceptible to contamination, as patients who accept participation presumably are motivated to exercise, and therefore typically unblinded. Due to lack of reporting on adherence in two studies [31,32] and the uncertainty regarding control participants' physical activities, it was not possible to determine if non-adherence and/or contamination could explain the lack of documented effects in most outcomes.
Another explanation for the lack of effect could be that the duration and/or intensity of the exercise programs were too short/low to make statistically significant differences. Although the intervention period in Arietta et al was long (12 months), the exercise intensity was unknown as it was adjusted to each participant's motivation and capability and was not further described [30]. In the study by Maréchal et al [31], the prescribed exercise intensities were well described. However, no reports on actual exercise adherence was provided [31]. Miki et al [33] investigated the effect of four speed-feedback sessions. Even though the intervention was targeted at improving cognitive function, the study was included in this systematic review as it involved some degree of exercising. However, with only four sessions, each with a pedaling time of 5 min and an exercise load at 20 watts, the intervention is unlikely to have any effects on physical outcomes. The secondary outcomes included in the study (ADL, IADL and FACT-G) could potentially change due to cognitive improvements; yet no statistically significant differences were found, possibly due to the overall good functional status of the participants [33]. Sajid et al [32] provided detailed descriptions of the exercise intensities regarding both the walking program and the resistance exercises. However, while participants in the EXCAP group statistically significantly increased their number of daily steps, no other reports on exercise adherence were provided [32].
Two of the included trials were home-based [30,32]. While research has shown that most patients with cancer or cancer survivors prefer home-based exercise [42], it has also been demonstrated that supervised exercise programs are more effective than non-supervised [43]. In a systematic review investigating exercise preferences among older adults, preferences to exercise settings and social contexts varied [44]. However, accessibility of the location seemed to be more important than the type of location [44]. Hence, accessibility should be carefully considered in future exercise-based trials among older patients with cancer.
Overall, the included studies used relevant outcome variables and assessment methods. However, only one study used patient reported outcome measures (PROMs) to investigate the effect on HRQoL; Miki et al [33] measured the effect on FACT-G and found no statistically significant differences between groups. The use of PROMs in health care research has increased in the recent years [45]. By using PROMs, researchers can capture outcomes that are highly important to patients, such as physical and psychological health, social functioning, and distress from symptoms and side effects [45]. Therefore, it must be considered as highly relevant to include PROMs in future exercise-based intervention studies among older patients with cancer.

Strengths and limitations
This systematic review has some limitations. The large differences between studies in patient characteristics, interventions, outcome variables and assessment methods did not support the use of meta-analysis. Therefore, in accordance with the Cochrane Handbook [46], the results were described narratively. The inclusion of the speed-feedback study conducted by Miki et al [33] is contentious due to the very limited physical exercise component in the intervention. However, as it fulfilled all inclusion criteria, the study was included. Nevertheless, the results from this study must be interpreted with caution as it primarily investigates cognitive training. In hindsight, a more precise definition of the eligibility criteria and exercise interventions would have been preferable.
Even though the studies in this review solely included patients with cancer ≥65 years, it must be emphasized that most participants had few comorbidities, good PS, and no cognitive deficits. Therefore, the results may not be generalizable to all patients in the older cancer population.
In two of the included studies more than 50%, but not all participants, received systemic oncological treatment [30,33]. Therefore, the results from these two trials must be interpreted with caution in answering our research question.
We only searched for and included RCTs that solely focused on patients ≥65 years, which was limited to four studies. In addition, two studies had very small sample sizes (< 20), which increases the risk of biased results. In hindsight, several exercise-based RCTs have been conducted among patients with cancer, and even if older patients in general are underrepresented in exercise-based trials, some trials have a reasonable representation of older individuals [47,48] and/or may provide age-divided results.
Strengths of the review include the systematic approach guided by the Cochrane Handbook. The search was conducted in four databases, and the included studies were reviewed and assessed by two authors firstly independent and then by discussion to consensus.

Implications
Larger RCTs of high-quality are needed to further investigate the effect of exercise training on physical function, physical capacity, and HRQoL among older patients with cancer during systemic oncological treatment.

Conclusion
We have summarized the effects of exercise on HRQoL, physical function, aerobic capacity, and additional physical, cognitive and clinical outcomes among older patients (≥ 65 years) with cancer during systemic oncological treatment. Evidence for the effect of exercise interventions in this population is limited. Reasons for the limited effects could be caused by failing intervention, but also reflect limitations in the included studies, including small sample sizes. In all, the effects of exercise in older patients with cancer receiving medical antineoplastic treatments are inconclusive.