Balance dysfunction and falls in people with lower limb arthritis: factors contributing to risk and effectiveness of exercise interventions
© European Group for Research into Elderly and Physical Activity (EGREPA) 2011
Received: 22 August 2010
Accepted: 18 August 2011
Published: 2 September 2011
Chronic musculoskeletal conditions in the lower extremities, particularly arthritis, and the chronic pain associated with them, are independent risk factors for falls, with approximately 50% of people with arthritis reporting one or more falls. Despite this, few studies have specifically addressed balance dysfunction, falls risk and falls incidence in people with arthritis. This review aimed to identify potential factors contributing to the increased risk of falls in people with lower limb osteoarthritis or rheumatoid arthritis and to summarise the evidence base for effective exercise interventions targeted to reduce their risk of falls. A systematic search of the literature was conducted in February 2010 and included the following databases: MEDLINE (Ovid), EMBASE, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine, Cochrane Library and PsycINFO. Only three studies that investigated exercise programmes for people with lower limb arthritis met all inclusion criteria, but none used falls as an outcome measure. To broaden the review, systematic reviews that assessed the effectiveness of exercise interventions for fall prevention in older people were also included. The presence of any form of lower limb arthritis and the associated consequences including pain, balance impairment, reduced muscle strength and reduced function are all associated with increased risk of falling. Due to the link between musculoskeletal pain and the increased risk of falls, further research needs to investigate which type of exercise programme will be effective in reducing the risk of falls in populations with arthritis in the lower limbs.
Falls are among the most common cause of injury and hospital admissions in older people in Australia  and the leading cause of mortality and morbidity in people aged 65 years and over worldwide [2, 3]. Falls among older people in the community have been identified as a major public health problem with an estimated 30% of community-dwelling adults over the age of 65 reporting one or more falls each year [4–7]. The cost to the health care system associated with falls-related hospitalisation constitutes a substantial proportion of the burden of disease and health expenditure [8, 9]. Injuries sustained from falling not only have a negative impact upon function, independence and quality of life but are also one of the major predictors of need for residential care services. Recovery from falls is often difficult and can result in self-imposed functional limitations due to fear of future falls, which consequently may lead to post-fall anxiety syndrome, depression and social isolation [10, 11].
Studies have identified a large number of risk factors associated with the risk of falling. Risk factors are generally classified into extrinsic (environmental) and intrinsic (individual-related) factors [12, 13]. Falls usually result from an interaction of multiple factors, with the risk of falling increasing as the number of risk factors increases [3, 14]. Physiological factors such as lower extremity muscle weakness, gait and balance impairments and functional impairments have been strongly associated with the risk of falls and are often targeted in preventive programmes [3, 4, 15–20]. Although many factors contribute to the risk of falling, addressing preventable or reversible motor deficits through exercise programmes seems to be a key aspect for effective and successful intervention to reduce the risk of falls [21, 22].
Arthritis is one of the leading causes of disability among people aged 65 years and over in Australia and internationally [23, 24], with half of all people aged over 80 having some form of arthritis . Arthritis and musculoskeletal conditions accounted for approximately $23.9 billion of the health expenditure in Australia in 2007 and have been described as reaching epidemic levels . Similar high costs and projections have been reported internationally . Chronic musculoskeletal conditions in the lower extremities, particularly arthritis, and the chronic pain associated with them, have been shown to be independent risk factors for falls [4, 27–33]. Recent studies identified approximately 50% of samples of people with arthritis reported one or more falls in a 12-month period, which is higher than the 30–35% reported for older people living in the community [34–36]. Despite this, few studies have specifically addressed falls risk and falls incidence in people with arthritis and other musculoskeletal conditions. The purposes of this review were to identify potential factors contributing to the increased risk of falls for people with arthritis and related musculoskeletal conditions and to summarise the evidence base for effective exercise interventions targeted to reduce the risk of falls in this population.
Inclusion and exclusion criteria
Randomised controlled trials, prospective studies and case–control studies published in English evaluating falls, falls risk and exercise interventions in older people living in the community with arthritis-related conditions were considered for inclusion. Studies assessing older people in residential care settings or hospital settings were excluded. The search was limited to arthritis-related conditions, primarily osteoarthritis and rheumatoid arthritis. However, findings from research involving these two common forms of arthritis are likely to be generalisable to people with other arthritic conditions affecting the lower limbs.
A systematic search of the literature was conducted in February 2010 and included the following databases: MEDLINE (Ovid), EMBASE, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine, Cochrane Library and PsycINFO. Reference lists of key studies and systematic reviews were also examined. The search was limited to the English language and included the following keywords: falls, arthritis, osteoarthritis, rheumatoid arthritis, exercise, exercise therapy and balance. An example of a search strategy utilised for this review is presented in the “Appendix”.
All titles and abstracts identified in the database search were exported to EndNote version X3 (Thomson, Reuters, Carlsbad, CA, USA). Any duplicated references were deleted. Each title and abstract was initially reviewed by one reviewer, and papers not relevant to the review were excluded. Potentially relevant papers were retained and were reviewed by a second reviewer independently to determine suitability for inclusion.
The literature search revealed over 3,000 potential studies. Only three studies (two randomised controlled trials and one pre-post design) of exercise interventions (home-based exercise programme, Tai Chi and aquatic exercise programme) aiming to reduce falls risk and improve balance in people with arthritis were identified that met all inclusion criteria [35, 37, 38]. To broaden the review, systematic reviews that assessed the effectiveness of exercise interventions for fall prevention in older people were also included [21, 22]. Further to this, relevant papers that investigated physical factors such as balance, strength and proprioception associated with arthritis and increased risk of falling were also included.
Physical factors associated with arthritis and increased risk of falls
Balance and proprioception
Balance is an integral part of daily activities and important for independent function in older people. The ability to perform functional activities is multifaceted and involves other important components such as muscle strength, proprioception and neuromuscular control. As part of the ageing process, physiological changes in the neuromuscular system such as reduction in muscle strength, proprioception, reaction time and other components of the sensory system affect balance control and consequently have an adverse effect on the functional ability of older people [39–42]. Balance impairment has been shown to be a risk factor for falls in older people [3, 19, 43–45], including a recent systematic review in community-dwelling older adults . People with lower limb arthritis have been reported to have proprioceptive deficits and poor balance control compared with asymptomatic controls [46–49]. People with knee osteoarthritis showed increased postural sway as measured by the movement of the centre of pressure [47, 48] or by the use of clinical tests , poorer proprioceptive acuity of affected joints  and impaired sensorimotor function .
Lower limb muscle weakness
Loss of muscle mass and reduction of strength that occur with increasing age are important contributing factors to reduced function and increased falls risk. Epidemiological studies have reported that approximately 1% of muscle mass is lost per year after the fourth decade of life [53, 54]. Muscle strength has been shown to be an important factor in balance and gait, and muscle weakness has been shown to be a risk factor for the occurrence of falls [15, 20, 55, 56]. People with lower limb arthritis are commonly reported to have reduced muscle strength and poor muscle control compared with asymptomatic individuals [47, 51, 57–59]. Muscle weakness around the knee and hip for people with knee and hip arthritis has been reported to be present in between 20% and 70% of people for the knee [47, 51, 59, 60] and 20% to 31% for the hip [57, 58, 61]. The presence of arthritis negatively affects the structure and function of muscle integrity and sensory functions, which in turn are likely to influence balance and compromise the safe performance of daily activities.
Pain and functional limitation
Disease symptoms associated with arthritis, such as pain in the lower limb, are related to deficits in neuromuscular functioning and may be an important underlying mechanism contributing to increased risk of falls and disability. Musculoskeletal pain may predispose to falls as it contributes to muscle weakness and mobility limitation . One study reported that musculoskeletal pain, particularly widespread pain, was shown to be substantial risk factors for falls with 60% increased risk of falls for women who had a significant symptom of arthritis and other musculoskeletal disorders . Similarly, patients with hip pain had increased risk of falling (41% reported retrospectively having fallen compared with 16% of controls) regardless of the presence or absence of radiographic signs of hip osteoarthritis . An association between pain and dysfunction, but not radiographic osteoarthritis and physiological predictors of falls risk, was also reported in the Tasmanian Older Adult Cohort study . Leveille and colleagues  examined the association between chronic musculoskeletal pain and the occurrence of falls and found that chronic pain in more than one location and increased pain severity were associated with greater risk of falls. In summary, the presence of any form of lower limb arthritis and the associated consequences including pain, balance impairment, reduced muscle strength and reduced function are all associated with increased risk of falling.
Other falls risk factors
People with lower limb arthritis may have a range of other health problems that also increase their risk of falling. For example, poor eyesight, polypharmacy and the use of psychotropic medications, vestibular (inner ear) problems and peripheral neuropathy can all increase the risk of falling, independent of whether a person has arthritis or not [12, 13, 16, 65]. All falls risk factors should be identified, and where possible, interventions should be implemented to address these. This may involve assessment with a falls risk assessment tool such as the FROP-Com  or the Falls Quickscreen .
Non-exercise interventions to reduce the risk of falls
Improving vision through cataract surgery
Psychotropic medication withdrawal
Medication review and recommendations to reduce or change medications
Enhanced care after discharge home from hospital
Home safety modifications by a trained health professional for people with increased falls risk
In addition, multifactorial interventions, where two or more types of interventions are combined, often based on a detailed falls risk assessment have also been shown to be effective in a number of randomised trials, even in people with high falls risk .
Exercise interventions to reduce the risk of falls in arthritis population
Systematic reviews have highlighted the effectiveness of exercise interventions in the reduction of falls among older people living in the community [21, 22]. Gillespie et al. reported that exercise programmes that contain two or more components (strength, balance, flexibility or endurance) are more effective in reducing the rate of falls and the number of people falling compared to a single exercise component interventions programmes . Within the exercise interventions, multiple component group exercise, Tai Chi (as a group exercise) and individually prescribed multiple component exercise carried out at home were all effective in reducing both the rate of falls and risk of falling. Sherrington et al. reported that exercise interventions that include a balance component are more effective for falls prevention than other forms of exercises . This review also identified that exercise dose (>50 h cumulative exercise amount, irrespective of exercise frequency) is associated with the efficacy of exercise programmes. Although both systematic reviews provide evidence for the effectiveness of exercise in reducing falls in older people in the community [21, 22], none of the included randomised controlled trials in these reviews primarily target an arthritis population, and therefore, the effect of exercise interventions on the reduction of falls in people with lower limb arthritis remains unknown. Several studies have reported the presence of musculoskeletal conditions in their population demographic; however, they have not indicated the effectiveness of the intervention to these people as a separate sub-group [68–70].
Only three studies were identified which investigated the effect of exercise programmes (home-based exercise programme, Tai Chi and aquatic exercise programme) to improve balance and the risk of falls in people with lower limb osteoarthritis and rheumatoid arthritis [35, 37, 38]. Williams et al. used an individualised balance and strength exercise programme, together with a graduated walking programme, over a 4-month intervention for people with rheumatoid arthritis and osteoarthritis and reported a significant improvement in balance, mobility, activity level, fear of falling and reduction in falls risk. While this study provides promising results, it was not powered to evaluate whether the exercise intervention reduced falls and was not a randomised trial design . Song et al., using a randomised control trial, investigated the effectiveness of a 6-month Tai Chi programme on knee extensor muscle strength and fear of falling in women with knee osteoarthritis . A significant improvement in knee strength and reduced fear of falling were reported; however, the effectiveness of the programme in reducing the number of falls remains unknown. Similarly, 11 weeks of combined educational programme (focused on increase knowledge on fall risk factors and falls prevention strategies) and aquatic exercise (focused on mobility, strength and balance) resulted in improvement in falls efficacy . A longer follow-up however is needed to investigate the effect of the combined intervention programme on falls prevention. Consequently, none of the above studies have evaluated the effectiveness of exercise or other falls prevention approaches in reducing falls in people with lower limb arthritis.
Despite the evidence that muscle weakness is a risk factor for falls , strength training with moderate or high intensity in isolation has not been shown to reduce risk of falls . Since balance impairment is associated with increased fall risk  and resistance (strengthening), exercise alone has not been consistently shown to improve balance in older adults (based on limited evidence) , balance impairment may be a stronger risk factor and therefore important to include in intervention programmes for falls prevention. Nevertheless, strength exercises may be important for people with musculoskeletal conditions as they have been shown to improve pain and disability for people with osteoarthritis . Non-surgical treatment for arthritis commonly includes exercises aiming to reduce symptoms, increase function and muscle strength and improve joint integrity, but usually do not incorporate balance assessment or balance training. Due to the association between pain and the occurrence of falls in people with arthritis, it is likely that a combined balance, strengthening, flexibility and functional retraining exercise programme may provide a holistic approach to optimising a range of health outcomes, including improved balance and reduced falls risk.
Exercise in warm water has a range of benefits for people with some forms of arthritis, although there have been no randomised trials evaluating the effectiveness of this exercise approach in reducing falls. However, water exercise programmes can include exercises that involve strengthening of lower limb muscles and balance-related activities, which have been shown to achieve significant improvements in balance performance and function in people with arthritis in a pre-post design study . Randomised controlled trials are required to investigate whether water exercise programmes with a balance component can reduce falls in people with arthritis.
In summary, exercise is one of the most researched types of interventions that have been shown to be effective in reducing falls in older people. However, it is important to note that there are different types of exercise that have differing effects on reducing falls and other health outcomes and that rarely has the focus of exercise in falls prevention targeted people with arthritis. Balance exercises should form part of an exercise programme aiming to reduce falls.
Barriers for exercise in people with arthritis
The health benefits of physical activity on life expectancy and quality of life have been well established [75–77]. Despite the clear health benefits of physical activity, many people in the community are still living a sedentary lifestyle. The national physical activity recommendations for older Australians recommend that older people should do some form of physical activity irrespective of their age, weight, health problems or abilities . Pain has been recognised as a major barrier for participation in physical activity and social interaction in people with arthritis [79–82], with studies suggesting a strong association between pain, depression and anxiety [83, 84]. Pain affects people's mood and ability to perform daily life activities; this in turn can be transmitted into other areas of life, leaving people with more difficulty engaging in social and leisure activities . Physical activity has been shown to improve quality of life, function and disability and can alleviate pain in people with musculoskeletal conditions [73, 86–88]. The beneficial effects of exercise, however, seem to decline over time due to problems with adherence . Active involvement, motivation strategies and long-term goals should be implemented in the intervention programme to support long-term behaviour change and adherence to physical activity . Other factors influencing physical activity participation in older people generally, which are likely to also be relevant to people with arthritis, include ease of access, the choice in type of physical activity programme (e.g. home versus centre based), cost and opportunity for social networking [91–93].
For people with painful lower limb joints associated with musculoskeletal conditions, incorrect exercise selection or performing exercises at too high intensity or dosage (for example doing too many repetitions of a specific exercise) might increase pain [94, 95]. The pre-post design home exercise and aquatic exercise studies that achieved improved balance, mobility and falls risk outcomes for people with osteoarthritis and rheumatoid arthritis reported no significant change in joint pain with these exercise programmes [35, 38]. People with arthritis affecting the lower limb joints with concerns about the best form of exercise to undertake should consider having an assessment by a trained health professional such as a physiotherapist or exercise physiologist to determine the most appropriate type and amount of exercise to commence with and how this can be progressed.
The attitudes and beliefs towards exercise in people with arthritis play a significant role in the participation and adherence to physical activity [96, 97]. Some common reasons given by people with arthritis and other chronic health conditions about why they do not participate in physical activity or exercise programmes include that they consider exercise could aggravate their condition, that their health status means that they should not participate in physical activity or exercise programmes [81, 82] and that they are ‘too old’. As the recently Commonwealth Government-endorsed Australian recommendations for physical activity for older people highlight, none of these should be a barrier to participating in physical activity [78, 98] but health professional advice may be needed for those with concerns. Given the substantial evidence of the benefits of various forms of exercise (such as land-based exercise, aquatic, muscle strengthening and aerobic exercise) for people with arthritis in reducing pain and disability [73, 86–88, 99–103], exercises are unlikely to be harmful if prescribed based on an assessment of individual need.
Clinical implications and recommendations
Despite, the high prevalence of falls in people with arthritis, there is a paucity of studies that investigate exercise interventions to reduce falls for people with lower limb arthritis. While some general indications can be derived from the extensive falls prevention literature for older people generally (including that to reduce falls, the exercise programme should incorporate exercises that challenge the balance system), there are some unique characteristics of impairments associated with the various forms of lower limb arthritis that highlight the need for research specifically targeting people with lower limb arthritis. For example, if incorrect exercises are undertaken, if there is excessive joint loading or any exercise is performed too vigorously, it may aggravate joint pain, inflammation and swelling. Greater levels of care may need to be used when commencing a new type of exercise programme, such as a balance training programme, for people with lower limb arthritis.
General recommendations from the American College of Sport Medicine focus on joint protection exercises and include low-impact activity and functional exercise strengthening, and avoidance of contact sports and other activities requiring prolonged one-legged stance or rapid action movement in people with symptomatic joints . Exercise for people with lower limb arthritis therefore may need to be individually tailored to fit the person's need and to minimise the risk of aggravating their joint pain. Seeking medical and other health professional advice should be considered before starting a new type of exercise programme.
There is a clear need for quality randomised controlled trials to evaluate the effectiveness, cost effectiveness and factors influencing successful outcomes in improving balance, reducing falls and improving long-term outcomes for people with lower limb arthritis.
Summary and key points
Falls prevention programmes that target single and multiple falls risk factors in older people have been shown to be successful in reducing falls. Similar approaches should be utilised to address non-arthritis-related falls risk factors (e.g. cataracts and psychotropic medication use) in people with arthritis who present with these comorbidities or falls risk factors.
The presence of any form of lower limb arthritis and the associated consequences including pain, balance impairment, reduced muscle strength and reduced function are all associated with increased risk of falling.
There are no randomised controlled trials investigating exercise interventions to reduce falls in people with arthritis. Since there is a link between musculoskeletal pain and increased risk of falls, further research is required to investigate which type of exercise programme will be effective in reducing the risk of falls specifically in populations with lower limb arthritis.
Pain can be a perceived barrier for exercise in people with arthritis. Given the considerable evidence of the benefits of exercise in reducing pain, exercise aiming at reducing disease symptoms may be an important component to be included in any intervention in this population.
Clinicians and other health care professionals should aim to identify concerns of people with arthritis with regard to exercise and pain and provide support and information to strongly encourage participation in appropriate exercise programmes.
Due to the benefits of exercise for pain reduction and physical functioning, regular moderate intensity exercise is safe and should be encouraged in individuals with arthritis. People with moderate to severe arthritis, or painful lower limb joints, should consult a physiotherapist or other health professional regarding the most appropriate exercises to reduce falls that are suitable for their level of symptoms and disease severity.
An effective intervention programme for falls prevention for people with arthritis may need to include both balance exercises and exercises to reduce disease symptoms.
Funding was provided by Arthritis Victoria for undertaking the review.
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